The Clinical Guide to Fading Hyperpigmentation


Hyperpigmentation is not just a cosmetic flaw but a biological reaction of the skin to external and internal factors such as ultraviolet radiation, hormonal fluctuations, inflammatory processes, and age-related changes, with each of these triggers leaving its own “imprint” in the form of dark spots that may appear on the face, neck, or hands, essentially becoming a “skin diary” that records time spent under the sun, periods of stress, and the aftereffects of acne (Skin Therapy Letter, Vogue, ResearchGate).

Main Causes of Dark Spots

The most common triggers include UV exposure, which activates melanocytes and increases melanin synthesis, leading to new pigmentation areas; hormonal changes, associated with pregnancy, oral contraceptives, or stress, which often provoke melasma; inflammatory processes such as post-inflammatory hyperpigmentation (PIH), which leave persistent marks even after acne heals; and age-related slowing of skin cell renewal, which allows pigment to remain longer in the skin and makes dark spots more visible (Journal of Cosmetic Dermatology, ScienceDirect).

Clinical studies indicate that up to 92% of hyperpigmentation cases respond significantly to the right skincare regimen combined with consistent sun protection, and for sensitive or reactive skin, it is particularly important to use gentle yet effective formulas, since overly aggressive treatments can worsen pigmentation or cause new marks to form (PMC).

Clinically Proven Ingredients for Even Skin Tone

Glycolic Acid (8%) — an alpha-hydroxy acid (AHA) that accelerates skin cell turnover and gradually lightens pigmentation (ScienceDirect).
Kojic Acid (2%) — a tyrosinase inhibitor that reduces melanin production and prevents new dark spots.
Phenylethyl Resorcinol (0.5%) — a potent melanin synthesis suppressor shown in clinical trials to outperform kojic acid (PMC).
Niacinamide — helps even skin tone and blocks melanin transfer to keratinocytes (Journal of Cosmetic Dermatology).
SPF 50+ Broad Spectrum — non-negotiable, as preventing new pigmentation is just as important as treating existing spots.

Recommended AM & PM Routine with Canova

Morning: gentle cleansing, antioxidant serum, then DEPI 50+ Brightening Cream SPF 50 — a day cream combining high-level sun protection with corrective brightening action, ideal for sensitive skin.

Evening: gentle exfoliant (glycolic + kojic acids), restorative treatment, and targeted brightening concentrate — RESURFACE X3 DEPISERUM, containing 0.5% phenylethyl resorcinol, niacinamide, vitamin E, and antioxidants, offering precise correction for dark spots in a lightweight, fragrance-free formula. Finish with 8+2 Lightening Cream, a night treatment with glycolic and kojic acids to fade pigmentation and protect skin with antioxidants (Allure, canova.it).

Conclusion

Hyperpigmentation is not a flaw but a mark left by life events, and modern dermatology offers real correction, not just coverage, with scientifically proven formulas that act deep within the skin while remaining gentle. Consistency, the right combination of actives, and uncompromising sun protection form the foundation for lasting results, allowing the skin to look even, fresh, and healthy.

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